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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CIR1
All Species:
14.55
Human Site:
S421
Identified Species:
29.09
UniProt:
Q86X95
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q86X95
NP_004873.3
450
52313
S421
E
Q
S
R
R
N
D
S
R
S
H
G
T
D
L
Chimpanzee
Pan troglodytes
XP_001148591
450
52340
S421
E
Q
S
R
R
N
D
S
R
S
H
G
T
D
L
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_535968
475
55209
T428
K
R
N
G
K
N
D
T
R
S
H
G
T
D
A
Cat
Felis silvestris
Mouse
Mus musculus
Q9DA19
450
51819
P422
H
R
E
V
R
S
R
P
H
R
S
P
S
E
E
Rat
Rattus norvegicus
Q5U2T8
451
51398
R420
K
H
R
E
R
E
A
R
S
R
P
H
Q
S
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514863
861
95412
T428
N
E
A
R
S
C
N
T
D
V
Q
R
E
G
K
Chicken
Gallus gallus
Q5ZI03
460
53359
T415
E
R
H
R
K
N
E
T
R
S
P
S
T
D
G
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_689017
177
20337
N149
L
F
G
L
S
G
I
N
A
S
S
M
A
G
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_649072
366
43629
R338
S
N
E
N
R
H
R
R
D
R
S
R
S
R
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_491654
560
65813
S494
A
S
P
R
R
R
R
S
P
S
P
E
R
Q
R
Sea Urchin
Strong. purpuratus
XP_794696
488
58217
D454
K
E
S
R
R
D
R
D
R
D
G
G
E
K
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8VZ67
595
69129
R497
K
E
H
R
Y
D
E
R
R
H
R
Y
V
D
M
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
N.A.
84
N.A.
80.2
80.2
N.A.
43.5
70
N.A.
33.3
N.A.
38.4
N.A.
36.4
41.3
Protein Similarity:
100
99.5
N.A.
89.4
N.A.
86
86.6
N.A.
48.3
81.5
N.A.
36.6
N.A.
52.4
N.A.
51.2
56.5
P-Site Identity:
100
100
N.A.
53.3
N.A.
6.6
6.6
N.A.
6.6
46.6
N.A.
6.6
N.A.
6.6
N.A.
26.6
33.3
P-Site Similarity:
100
100
N.A.
86.6
N.A.
33.3
13.3
N.A.
33.3
73.3
N.A.
13.3
N.A.
20
N.A.
26.6
53.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.3
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
41
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
53.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
9
0
0
0
9
0
9
0
0
0
9
0
9
% A
% Cys:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
17
25
9
17
9
0
0
0
42
25
% D
% Glu:
25
25
17
9
0
9
17
0
0
0
0
9
17
9
9
% E
% Phe:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
9
9
0
9
0
0
0
0
9
34
0
17
9
% G
% His:
9
9
17
0
0
9
0
0
9
9
25
9
0
0
0
% H
% Ile:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% I
% Lys:
34
0
0
0
17
0
0
0
0
0
0
0
0
9
9
% K
% Leu:
9
0
0
9
0
0
0
0
0
0
0
0
0
0
17
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
9
% M
% Asn:
9
9
9
9
0
34
9
9
0
0
0
0
0
0
0
% N
% Pro:
0
0
9
0
0
0
0
9
9
0
25
9
0
0
9
% P
% Gln:
0
17
0
0
0
0
0
0
0
0
9
0
9
9
0
% Q
% Arg:
0
25
9
59
59
9
34
25
50
25
9
17
9
9
9
% R
% Ser:
9
9
25
0
17
9
0
25
9
50
25
9
17
9
0
% S
% Thr:
0
0
0
0
0
0
0
25
0
0
0
0
34
0
0
% T
% Val:
0
0
0
9
0
0
0
0
0
9
0
0
9
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
9
0
0
0
0
0
0
9
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _